Is Naproxen Safe During Pregnancy?

Is naproxen safe during pregnancy?

Naproxen is an NSAID the FDA warns against from 20 weeks onward because it can reduce fetal kidney function and amniotic fluid, and after about 30 weeks can prematurely close the fetal ductus arteriosus. In short, naproxen is best avoided during pregnancy when you follow the guidance below.

Why this is the guidance

Almost any medication you take can cross the placenta, so the question is never just “does it work” but “is the benefit worth any possible effect on the baby at this stage.” Many common drugs have safer pregnancy-friendly alternatives, and the safest choice can change by trimester.

Safer alternatives

Naproxen isn't recommended in pregnancy, but you rarely have to just tough it out — there's usually a pregnancy-safe alternative for the same problem. Don't start or stop anything important on your own: ask your provider or pharmacist for the safe swap before you need it.

What about breastfeeding?

Pregnancy and breastfeeding aren't the same — some things that are limited while you're pregnant are perfectly fine once you're nursing, and occasionally the reverse is true. If you're past delivery and wondering about naproxen while breastfeeding, check with your provider, since the answer can be different from the pregnancy guidance above.

The bottom line

Naproxen: best avoided in pregnancy. When in doubt, choose a safer alternative and ask your provider. This page is general education, not medical advice — your provider knows your history and is the final word for your pregnancy.