Enfamil Enspire Optimum vs Similac 360 Total Care
Head-to-head in best baby formula, scored on our six-axis safety-first system.
Brands can't buy a ranking — our picks are scored safety-first, independently. When you buy through our links, your purchase helps fund that independent research, at no extra cost to you. As an Amazon Associate we earn from qualifying purchases. Full affiliate disclosure.
Baby Formula
Enfamil Enspire Optimumrobincove.Enfamil Enspire Optimum
8.3/10$42–$45/can
Our pick
Baby Formula
Similac 360 Total Carerobincove.Similac 360 Total Care
8.7/10$36–$40
Our verdict
Similac 360 Total Care takes it on our safety-first score (8.7 vs 8.3), helped most by 5 hmo prebiotics. The Enfamil Enspire Optimum still makes sense if its price or feature mix fits you better.
Who wins each category
9.0 ✓Safety8.8
8.4Ease of use✓ 9.0
6.8Value✓ 8.4
8.4Durability8.4
8.6Comfort8.6
9.0 ✓Features8.6
Baby Formula
Enfamil Enspire Optimumrobincove.Enfamil Enspire Optimum
$42–$45/can
Baby Formula
Similac 360 Total Carerobincove.Similac 360 Total Care
$36–$40
Safety
9.0
8.8
Ease of use
8.4
9.0
Value
6.8
8.4
Durability
8.4
8.4
Comfort
8.6
8.6
Features
9.0
8.6
Want more options? See our full ranking of best baby formula.