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Enfamil Enspire Optimum vs ByHeart Whole Nutrition

Head-to-head in best baby formula, scored on our six-axis safety-first system.

Brands can't buy a ranking — our picks are scored safety-first, independently. When you buy through our links, your purchase helps fund that independent research, at no extra cost to you. As an Amazon Associate we earn from qualifying purchases. Full affiliate disclosure.

Our pick

Enfamil Enspire Optimum

8.3/10$42–$45/can

ByHeart Whole Nutrition

8.3/10$38–$40/can

Who wins each category

9.0Safety9.0
8.4Ease of use8.4
6.8Value7.0
8.4Durability8.4
8.6Comfort8.6
9.0Features8.6
Our pick

Enfamil Enspire Optimum

$42–$45/can

ByHeart Whole Nutrition

$38–$40/can

Safety
9.0
9.0
Ease of use
8.4
8.4
Value
6.8
7.0
Durability
8.4
8.4
Comfort
8.6
8.6
Features
9.0
8.6

Want more options? See our full ranking of best baby formula.